Preferred Label : Anti-TROP-2 Antibody-drug Conjugate HS-20105;
NCIt synonyms : ADC HS-20105; Anti-TROP-2/Topoisomerase-1 Inhibitor ADC HS-20105; Anti-TROP-2 ADC HS-20105;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody targeting the tumor-associated antigen (TAA) trophoblast cell
surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2;
TACSTD2; GA733-1; M1S1) linked, via a cleavable linker, to a topoisomerase-1 inhibitor,
with potential antineoplastic activity. Upon administration of anti-TROP-2 ADC HS-20105,
the anti-TROP-2 antibody targets and binds to TROP-2 expressed on tumor cells. Upon
binding, internalization and linker cleavage, the topoisomerase-1 inhibitor is released,
and inhibits DNA topoisomerase-1 activity, thereby inhibiting DNA replication and
resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of TROP-2-expressing tumor cells. TROP-2 is a transmembrane protein overexpressed
in various tumors. Its expression is associated with enhanced tumor aggressiveness,
metastasis, drug resistance and increased tumor cell survival.;
Molecule name : HS-20105; HS 20105;
NCI Metathesaurus CUI : CL1926432;
Origin ID : C204169;
UMLS CUI : C5908038;
Semantic type(s)
- concept_is_in_subset
- has_target
