Ornithine Aminotransferase, Mitochondrial

Preferred Label : Ornithine Aminotransferase, Mitochondrial;

NCIt synonyms : Ornithine Delta-Aminotransferase; Ornithine Keto Acid Aminotransferase; EC 2.6.1.13; Testicular Tissue Protein Li 130; Ornithine--Oxo-Acid Aminotransferase; Ornithine Aminotransferase; OAT; Ornithine-Oxo-Acid Aminotransferase;

NCIt definition : Ornithine aminotransferase, mitochondrial (439 aa, 49 kDa) is encoded by the human OAT gene. This protein plays a role in the reversible conversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.;

NCIt note : Ornithine aminotransferase, mitochondrial is proteolytically processed in a tissue-specific manner. Removal of the transit peptide via cleavage between alanine-25 and threonine-26 yields the hepatic form, while removal via cleavage between glutamine-35 and glycine-36 yields the renal form. (UniProt);

NCI Metathesaurus CUI : CL964464;

Details

Origin ID

C204106;

UMLS CUI

C4743333;

OMIM relation
- Ornithine aminotransferase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- OAT protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- OAT Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrial Matrix [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arginine and Proline Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Amino Acid Biosynthesis [NCIt concept]
- Biogenic Amine Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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