Molybdenum Cofactor Biosynthesis Protein 1

Preferred Label : Molybdenum Cofactor Biosynthesis Protein 1;

NCIt synonyms : EC 4.1.99.22; EC 4.6.1.17; MOCS1; Cell Migration-Inducing Gene 11 Protein; Molybdenum Cofactor Synthesis-Step 1 Protein A-B;

NCIt definition : Molybdenum cofactor biosynthesis protein 1 (636 aa, 70 kDa) is encoded by the human MOCS1 gene. This protein plays a role in the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP).;

NCIt note : Several MOCS1A and MOCS1B isoforms may be produced due to alternative splicing or independent translation of a bicistronic transcript. The MOCS1B isoform (also called MOCS1B Type-II) is the canonical form according to UniProt.; The GTP 3',8-cyclase (EC 4.1.99.22; molybdenum cofactor biosynthesis protein A) and cyclic pyranopterin monophosphate synthase (EC 4.6.1.17; molybdenum cofactor biosynthesis protein C) activities of molybdenum cofactor biosynthesis protein 1 are likely dependent on the formation of complexes containing both isoform MOCS1A and isoform MOCS1B. (UniProt);

Details

Origin ID

C203811;

UMLS CUI

C1447692;

OMIM relation
- Molybdenum cofactor synthesis gene 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MOCS1 protein, human [MeSH Supplementary Concept]
- MOCS1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Lyase Gene [NCIt concept]
- MOCS1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Folate Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients