S-Adenosylmethionine Synthase Isoform Type-1

Preferred Label : S-Adenosylmethionine Synthase Isoform Type-1;

NCIt synonyms : Methionine Adenosyltransferase I/III; MAT1A; MAT 1; MAT-I/III; AdoMet Synthase 1; Methionine Adenosyltransferase 1; EC 2.5.1.6; Methionine Adenosyltransferase 1A; S-Adenosylmethionine Synthetase; AdoMet Synthetase 1;

NCIt definition : S-adenosylmethionine synthase isoform type-1 (395 aa, 44 kDa) is encoded by the human MAT1A gene. This protein is involved in catalyzing the transfer of the adenosyl moiety of ATP to methionine, which yields S-adenosylmethionine, diphosphate (PPi) and phosphate (Pi).;

NCIt note : Endogenous S-adenosylmethionine synthase isoform type-1 occurs as a homotetramer (MAT-I) and a homodimer (MAT-III).;

Details

Origin ID

C203773;

UMLS CUI

C1671958;

OMIM relation
- Methionine adenosyltransferase I, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAT1A protein, human [MeSH Supplementary Concept]
- MAT1A protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAT1A Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Liver [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cysteine and Methionine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Amino Acid Biosynthesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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