" /> Autologous Anti-GPRC5D CAR-T Cells BMS-986393 - CISMeF





Preferred Label : Autologous Anti-GPRC5D CAR-T Cells BMS-986393;

NCIt synonyms : Autologous Anti-GPRC5D CAR-T Cells CC-95266; GPRC5D-targeted Autologous CAR T Cells BMS-986393; Autologous Anti-GPRC5D CAR T-cells BMS-986393;

NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D CAR-T cells BMS-986393 specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation.;

Molecule name : BMS-986393; CC-95266; BMS 986393; CC 95266;

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15/05/2024


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