Preferred Label : Anti-DLL3 ADC ZL-1310;
NCIt synonyms : ADC SC-002; Anti-DLL3 Antibody-drug Conjugate ZL-1310;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and linked to an as
of yet unelucidated cytotoxic agent, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-DLL3 ADC ZL-1310 targets and binds to DLL3 found
on DLL3-expressing tumor cells. Upon internalization, the cytotoxic agent causes cell
death in DLL3-expressing tumor cells through an as of yet unknown mechanism of action.
DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types.
It plays a key role in embryonic development and in tumor initiation and proliferation.;
Molecule name : YL 212; ZL-1310; YL-212; ZL 1310;
NCI Metathesaurus CUI : CL1922422;
Origin ID : C203531;
UMLS CUI : C5908008;
Semantic type(s)
- concept_is_in_subset
- has_target
