T Acute Lymphoblastic Leukemia with SPI1 Rearrangement

Preferred Label : T Acute Lymphoblastic Leukemia with SPI1 Rearrangement;

NCIt definition : T acute lymphoblastic leukemia characterized by the presence of SPI1 gene rearrangement. It has a poor prognosis.;

Neoplastic status : Malignant;

Details

Origin ID

C203428;

Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Peripheral (Post-Thymic) T-Lymphocyte [NCIt concept]
Disease may have findings
- Extensive Bone Marrow and Blood Involvement [NCIt concept]
- Hepatomegaly [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Malignant Pleural Effusion [NCIt concept]
- Splenomegaly [NCIt concept]
- Starry Sky Pattern [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- SPI1 Gene Rearrangement [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphoblast [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic T-Lymphoblast [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphoblast [NCIt concept]
- Lymphocyte [NCIt concept]
- Precursor T-Lymphoblast [NCIt concept]
- T-Lymphocyte and Natural Killer Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- NOTCH1 Gene [NCIt concept]
- SPI1 Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- del(9p21p22) [NCIt concept]
- inv(14)(q11;q32.1) [NCIt concept]
- t(10;14)(q24;q11) [NCIt concept]
- t(11;14)(p13;q11) [NCIt concept]
- t(11;14)(p15;q11) [NCIt concept]
- t(14;14)(q11;q32) [NCIt concept]
- t(1;14)(p32;q11) [NCIt concept]
- t(1;7)(p33;q35) [NCIt concept]
- t(7;10)(q34;q24) [NCIt concept]
- t(7;14)(q35;q32.1) [NCIt concept]
- t(7;19)(q34;q13) [NCIt concept]
- t(7;9)(q34;q32) [NCIt concept]
- t(7;9)(q34;q34.3) [NCIt concept]
- t(8;13)(p11;q11) [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]
- NOTCH1 Gene Mutation [NCIt concept]
pathogenesis_of_disease_involves_gene
- SPI1 Gene [NCIt concept]
- SPI1 wt Allele [NCIt concept]

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