Preferred Label : Bleximenib;
NCIt synonyms : Menin-KMT2A Interaction Inhibitor JNJ-75276617; Menin-MLL1 Interaction Inhibitor JNJ-75276617;
NCIt definition : An orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed
lineage leukemia (MLL; mixed-lineage leukemia 1; MLL1; myeloid/lymphoid leukemia;
histone-lysine N-methyltransferase 2A; KMT2A) proteins, with potential antineoplastic
activity. Upon oral administration, bleximenib inhibits the interaction between the
two proteins menin and MLL and the formation of the menin-MLL complex. This reduces
the expression of downstream target genes and results in an inhibition of the proliferation
of leukemic cells with either KMT2A alterations such as gene rearrangements (KMT2A-r),
duplications, and amplification, or nucleophosmin 1 gene (NPM1) alterations. The menin-MLL
complex plays a key role in the survival, growth, transformation and proliferation
of certain kinds of leukemia cells.;
UNII : DCN5WEN78T;
CAS number : 2654081-35-1;
Molecule name : JNJ 6617; JNJ-6617; JNJ 75276617; JNJ-75276617;
NCI Metathesaurus CUI : CL1922260;
Origin ID : C203103;
UMLS CUI : C5908989;
Semantic type(s)
- concept_is_in_subset
- has_target
