Preferred Label : Molecular Glue Degrader GLB-001;
NCIt synonyms : MGD GLB-001;
NCIt definition : An orally bioavailable molecular glue degrader (MGD) composed of an E3 ubiquitin ligase-binding
moiety that is conjugated, via a linker, to an as of yet undisclosed target protein,
with potential antineoplastic activity. Upon oral administration, MGD GLB-001 targets
and binds to the undisclosed target protein on tumor cells and to E3 ubiquitin ligase,
thereby creating a ternary complex. This induces E3 ligase ubiquitination and proteasome-mediated
degradation of the undisclosed target. This may result in an inhibition of tumor cell
growth in which the target protein is upregulated or dysregulated.;
Molecule name : GLB-C183-A-2; GLB 001; GLB-001;
Origin ID : C202928;
concept_is_in_subset
