Preferred Label : Alpha-PD1/IL2 Fusion Protein AWT020;
NCIt synonyms : Anti-PD-1-IL-2 Fusion Protein AWT020; PD-1-IL-2 Fusion Protein AWT020; aPD1-IL2 Fusion Protein AWT020;
NCIt definition : A bifunctional fusion protein comprised of a monoclonal antibody directed against
the human negative immunoregulatory checkpoint receptor programmed cell death protein
1 (PD-1; PDCD1; CD279) linked to an engineered, variant form of interleukin-2 (IL-2)
and IL2c mutein (No-alpha-IL-2), with potential immunostimulating and antineoplastic
activities. Upon administration of anti-PD-1-IL-2 fusion protein AWT020, the antibody
moiety specifically targets, binds to and blocks PD-1 expressed on tumor-infiltrating
lymphocytes (TILs) and thereby brings the IL-2 moiety to PD-1-expressing tumoral T-cells.
The IL-2 moiety binds to the interleukin-2 receptor (IL2R), activates pSTAT5, and
may activate and expand tumor-infiltrating T-cells. This may enhance the activity
of cytotoxic T-cells and potentiates T-cell-mediated immune responses against tumor
cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed
on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation
and effector function when activated by its ligands, programmed cell death-1 ligand
1 (PD-L1; B7-H1; CD274) and 2 (PD-L2); it plays an important role in tumor evasion
from host immunity. No-alpha-IL-2 cannot bind to IL-2 receptor-alpha (CD25, IL2Ra)
and does not activate regulatory T-cells (Tregs).;
Molecule name : AWT-020; AWT 020;
Origin ID : C202900;
concept_is_in_subset
- has_target
