Preferred Label : EDB-FN-targeting Gadolinium-based Contrast Agent MT218;
NCIt synonyms : ZD2-N3-Gd(HP-DO3A); Gadolinium-based Contrast Agent MT218; Peptidic Gadolinium-based MR Imaging Agent MT218; Fibronectin-targeting Gadolinium-based Contrast Agent MT218; GBCA MT218;
NCIt definition : A contrast agent composed of a peptide of seven amino acids targeting the extradomain
B (EDB) of fibronectin (FN) conjugated to the contrast agent gadolinium, with potential
contrast-enhancing activity upon magnetic resonance (MR) imaging. Upon administration
of EDB-FN-targeting gadolinium-based contrast agent MT218, the EDB-FN-targeting peptide
moiety targets and binds to EDB-FN overexpressed on various tumor cells. Upon MRI,
gadolinium produces a large magnetic moment and thus a large local magnetic field.
This enhances the relaxation rate of nearby protons and increases the signal intensity
of tissue images. This allows visualization and specific localization of EDB-FN-expressing
tumor cells. EDB of fibronectin, an oncogenic extracellular matrix protein, is expressed
in many aggressive solid human tumors, whereas it is not detectable in normal vessels
and tissues.;
Molecule name : MT-218; MT 218;
NCI Metathesaurus CUI : CL1921511;
Origin ID : C202653;
UMLS CUI : C5907977;
Semantic type(s)
- concept_is_in_subset
- has_target
