Extra Domain B Fibronectin

Preferred Label : Extra Domain B Fibronectin;

NCIt synonyms : Extradomain-B Fibronectin; B-FN; Fibronectin Isoform 7; Isoform 7 Fibronectin; Extra-Domain B Fibronectin; EDB FN; EDB-FN; Extra Domain B Splice Variant of Fibronectin; Fibronectin Containing EDB Domain; Extradomain B Fibronectin;

NCIt definition : Extra domain B fibronectin (2446 aa, 266 kDa) is encoded by the human FN1 gene. This protein is involved in tissue remodeling, tumor growth, tumor invasion and tumor-related angiogenesis.;

NCIt note : Extra domain B fibronectin is encoded by a splice variant of the FN1 gene and features an insertion of the 99 amino acid residue extra fibronectin type III B (EIIIB) domain. The EIIIB domain is only included in cell-associated forms of fibronectin and is not present in plasma fibronectin.;

PubMed : 35793468; 2646306;

Details

Origin ID

C202650;

OMIM relation
- Fibronectin 1 [OMIM gene]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Extracellular Matrix Protein Gene [NCIt concept]
- FN1 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Tumor Cell Invasion [NCIt concept]
- Wound Repair [NCIt concept]
is_target
- EDB-FN-targeting Gadolinium-based Contrast Agent MT218 [NCIt concept]

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