NCIt synonyms : CD19 x CD3 x CD2 Trispecific Antibody PIT565; Anti-CD19/CD3/CD2 Trispecific Antibody PIT565;
NCIt definition : A trispecific T-cell engager and antibody targeting the tumor-associated antigen (TAA)
CD19, the T-cell surface antigen CD3, and the T-cell co-stimulatory receptor CD2,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-CD19/anti-CD3/anti-CD2 trispecific antibody PIT565 targets and binds to CD3 and
CD2 on T-cells and CD19 expressed on tumor cells. The resulting cross-linkage may
trigger a potent cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor
cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell
lineage malignancies.;
Semantic type(s)