Preferred Label : Anti-HER3 Antibody-drug Conjugate SHR-A2009;
NCIt synonyms : Anti-HER3 ADC SHR-A2009;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) human monoclonal
antibody directed against human epidermal growth factor receptor 3 (HER3; ErbB3) conjugated
via a cleavable peptide linker to a cytotoxic DNA topoisomerase I inhibitor, with
potential antineoplastic activity. Upon administration of anti-HER3 ADC SHR-A2009,
the anti-HER3 antibody moiety targets and binds to HER3 expressed on tumor cells.
Upon binding, internalization and linker cleavage, the topoisomerase I inhibitor targets
and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between
topoisomerase I and DNA and resulting in DNA breaks, inhibition of DNA replication
and apoptosis in HER3-expressing tumor cells. HER3, a member of the epidermal growth
factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed
in tumors.;
Molecule name : SHR-A2009; SHR A2009;
NCI Metathesaurus CUI : CL1921234;
Origin ID : C202278;
UMLS CUI : C5907971;
Semantic type(s)
- concept_is_in_subset
- has_target
