Preferred Label : Anti-LILRB2 Monoclonal Antibody OR502;
NCIt synonyms : Anti-ILT4 Monoclonal Antibody OR502;
NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the inhibitory
immune checkpoint receptor immunoglobulin-like transcript 4 (LILRB2; ILT4; leukocyte
immunoglobulin-like receptor subfamily B member 2; lymphocyte immunoglobulin-like
receptor 2; LIR2; monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d),
with potential immunomodulating and antineoplastic activities. Upon administration,
anti-LILRB2 monoclonal antibody OR502 targets and binds to LILRB2. This prevents the
binding of LILRB2 ligands to their receptor and prevents LILRB2-mediated signaling.
This abrogates the immunosuppressive activities of LILRB2 in the tumor microenvironment
(TME), activates the expression of pro-inflammatory cytokines, including granulocyte
macrophage-colony-stimulating factor (GM-CSF) and tumor necrosis factor alpha (TNFalpha),
and enhances a cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. LILRB2,
a transmembrane protein and inhibitory member of the immunoglobulin-like transcript
(ILT) family of proteins, is expressed primarily by myeloid cells, including monocytes,
macrophages, dendritic cells (DCs) and granulocytes, and in certain tumors. It plays
a key role in tumor immune evasion.;
Molecule name : OR 502; OR-502;
Origin ID : C202231;
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