Preferred Label : Anti-CD73 Monoclonal Antibody HB0045;
NCIt synonyms : HB0038/HB0039; Anti-CD73 Monoclonal Antibodies HB0038 and HB0039 Combination Formulation HB0045; Monoclonal Antibodies HB0038 and HB0039; Anti-CD73 Inhibitor HB0045;
NCIt definition : A compound preparation composed of two monoclonal antibodies, HB0038 and HB0039, targeting
different epitopes of human ectoenzyme 5'-ecto-nucleotidase (cluster of differentiation
73; CD73; 5'-NT; ecto-5'-nucleotidase; NT5E), in a 1:1 molar ratio, with potential
immunomodulating and antineoplastic activities. Upon administration, anti-CD73 monoclonal
antibody HB0045 targets and binds to two different epitopes of CD73 on tumor cells.
HB0038 specifically binds to the catalytic domain composed of the N-terminus and C-terminus
of CD73, thereby sterically blocking the CD73-mediated conversion of extracellular
adenosine monophosphate (AMP) to adenosine. HB0039 specifically and allosterically
binds to the N-terminal region of CD73, thereby inhibiting the transition of CD73
from the inactive open conformation to a catalytically active closed conformation.
This inhibits its enzymatic activity and further prevents adenosine formation from
AMP. This prevents adenosine-mediated suppression of lymphocyte activity and increases
the activity of cytotoxic T-lymphocytes (CTLs). This also activates macrophages and
reduces the activity of both myeloid-derived suppressor cells (MDSCs) and regulatory
T-lymphocytes (Tregs). By abrogating the inhibitory effect on the immune system and
enhancing the CTL-mediated immune response against cancer cells, tumor cell growth
is decreased. CD73, a plasma membrane protein belonging to the 5'-nucleotidase (NTase)
family, is upregulated on a number of cancer cell types and catalyzes the conversion
of extracellular nucleotides, such as AMP, to membrane-permeable nucleosides, such
as adenosine; it plays a key role in adenosine-mediated immunosuppression within the
tumor microenvironment (TME) and promotes tumor growth.;
Molecule name : HB 0045; HB-0045;
NCI Metathesaurus CUI : CL1921220;
Origin ID : C202228;
UMLS CUI : C5907951;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
