Preferred Label : Allogeneic Anti-CD19 Gamma-delta CAR-T Cells UTAA09;
NCIt synonyms : Allogeneic Anti-CD19 CAR Gamma Delta T-cells UTAA09; Allogeneic Anti-CD19 CAR gdT-cells UTAA09;
NCIt definition : A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain
and delta chain T-cell receptors (TCRs) and that are transduced with a lentiviral
vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated
antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities.
Upon administration, allogeneic anti-CD19 gamma-delta CAR-T cells UTAA09 specifically
target and bind to tumor cells expressing CD19, thereby inducing selective toxicity
in CD19-expressing tumor cells. Gamma delta T-lymphocytes play a key role in the activation
of the immune system and do not require major histocompatibility complex (MHC)-mediated
antigen presentation to exert their cytotoxic effect. CD19 antigen is a B-cell specific
cell surface antigen overexpressed in B-cell lineage malignancies.;
Molecule name : UTAA 09; UTAA-09;
NCI Metathesaurus CUI : CL1921222;
Origin ID : C202226;
UMLS CUI : C5907949;
Semantic type(s)
- concept_is_in_subset
- has_target
