Preferred Label : Allogeneic Anti-CD19 CAR-gamma/delta T-cells QH103;
NCIt synonyms : Allogeneic Anti-CD19 CAR-gamma-delta T Cells QH103; Allogeneic CD19 CAR-gamma Delta T Cells QH103; Allogeneic Anti-CD19 CAR Gamma Delta T-cells QH103; Allogeneic Anti-CD19 CAR Gamma Delta T Cells QH103; Allogeneic CD19 CAR-gdT-cells QH103;
NCIt definition : A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain
and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential
immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD19
CAR-gamma/delta T-cells QH103 target and bind to CD19-expressing tumor cells, thereby
inducing selective toxicity in CD19-expressing tumor cells. Gamma/delta T-lymphocytes
play a key role in the activation of the immune system and do not require major histocompatibility
complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. CD19
is overexpressed on certain tumor cell types.;
Molecule name : QH 103; QH-103;
NCI Metathesaurus CUI : CL1921225;
Origin ID : C202225;
UMLS CUI : C5907948;
Semantic type(s)
- concept_is_in_subset
- has_target
