Juvenile Trabecular Ossifying Fibroma

Preferred Label : Juvenile Trabecular Ossifying Fibroma;

NCIt synonyms : Trabecular Juvenile Ossifying Fibroma; JTOF; Trabecular Ossifying Fibroma;

NCIt definition : A rare, benign fibro-osseous neoplasm that usually affects the jaws and predominantly arises in children and adolescents. It is characterized by prominent osteoid formation rimmed by osteoblasts in a fibrotic stroma. Patients usually present with painless jaw expansion that is associated with rapid growth and tooth displacement. Amplifications of MDM2 and RASAL1 genes have been detected in some cases. Recurrences have been reported in a minority of cases.;

Neoplastic status : Benign;

Details

Origin ID

C202205;

UMLS CUI

C3697892;

Disease excludes abnormal cell
- Malignant Cell [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Skull [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Trabecular juvenile ossifying fibroma (morphologic abnormality) [SNOMED CT concept]
disease_excludes_finding
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
disease_has_finding
- Benign Cellular Infiltrate [NCIt concept]
- Fibrotic Stroma Formation [NCIt concept]
- Osteoid Formation [NCIt concept]
- Rapidly Enlarging Mass [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Skull [NCIt concept]
disease_may_have_molecular_abnormality
- MDM2 Gene Amplification [NCIt concept]
- RASAL1 Gene Amplification [NCIt concept]

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