Preferred Label : Anti-TROP-2/MMAE Antibody-drug Conjugate LCB84;
NCIt synonyms : Anti-TROP-2/MMAE ADC LCB84;
NCIt definition : An antibody-drug conjugate (ADC) composed of Hu2G10, a humanized immunoglobulin G1
(IgG1) monoclonal antibody that targets the tumor-associated antigen (TAA) trophoblast
cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2;
TROP-2; TACSTD2; GA733-1; M1S1), conjugated via a beta-glucuronidase-cleavable linker
to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule
disrupting agent, with potential antineoplastic activity. Upon administration of anti-TROP-2/MMAE
ADC LCB84, the anti-TROP-2 antibody targets and binds to TROP-2 expressed on tumor
cells. Upon binding and internalization, MMAE is released upon cleavage by the cancer-associated
lysosomal enzyme beta-glucuronidase. MMAE binds to tubulin and inhibits its polymerization,
resulting in G2/M phase arrest and tumor cell apoptosis. This induces cell death in
TROP-2-expressing cancer cells. TROP-2 is a transmembrane protein overexpressed in
various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis,
drug resistance and increased tumor cell survival.;
Molecule name : LCB 84; LCB-84;
NCI Metathesaurus CUI : CL1921124;
Origin ID : C202102;
UMLS CUI : C5907944;
Semantic type(s)
- concept_is_in_subset
- has_target
