Pineoblastoma miRNA Processing Altered 2

Preferred Label : Pineoblastoma miRNA Processing Altered 2;

NCIt synonyms : Pineoblastioma-miRNA2; PB-miRNA2; Pineoblastoma miRNA Processing Altered Group 2;

NCIt definition : Pineoblastoma characterized by alterations in genes involved in miRNA biogenesis (DICER1, DROSHA, and DGCR8). It may manifest as a sporadic tumor or part of DICER1 syndrome. It affects older children and follows a more favorable course.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1921424;

Détails

Origin ID

C201968;

UMLS CUI

C5907877;

Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Flexner-Wintersteiner Rosette Formation [NCIt concept]
- Hemorrhage [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Homer Wright Rosette Formation [NCIt concept]
- Microcalcification [NCIt concept]
- Necrotic Change [NCIt concept]
Excludes anatomical site(s)
- Spinal Cord [NCIt concept]
Has associated anatomic sites
- Brain [NCIt concept]
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
- Pineal Gland [NCIt concept]
- Supratentorial Brain [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Aggressive Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Pineocytomatous Rosette Formation [NCIt concept]
- Well-Circumscribed Lesion [NCIt concept]
disease_excludes_normal_tissue_origin
- Germinal Layer [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Neuroectodermal Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
- Neoplastic Small Immature Neuroepithelial Cell [NCIt concept]
- Neoplastic Small Neuroepithelial Cell [NCIt concept]
disease_has_finding
- Increased Cellularity Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_grade
- Grade 4 [NCIt concept]
disease_has_normal_cell_origin
- Embryonic Cell [NCIt concept]
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
- Pinealocyte [NCIt concept]
disease_has_normal_tissue_origin
- Embryonic Tissue [NCIt concept]
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
- Pineal Parenchyma [NCIt concept]
disease_has_primary_anatomic_site
- Brain [NCIt concept]
- Central Nervous System [NCIt concept]
- Pineal Gland [NCIt concept]
disease_may_have_molecular_abnormality
- DGCR8 Gene Mutation [NCIt concept]
- DICER1 Gene Mutation [NCIt concept]
- DROSHA Gene Mutation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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