Preferred Label : DNA Polymerase Theta Inhibitor GSK4524101;
NCIt synonyms : Pol Theta Inhibitor GSK4524101; POLQi GSK4524101;
NCIt definition : An orally bioavailable inhibitor of DNA polymerase (pol) theta, with potential chemosensitizing
and antineoplastic activities. Upon oral administration, pol theta inhibitor GSK4524101
specifically targets, binds to and inhibits the activity of pol theta. This prevents
pol theta-mediated repair of double-stranded DNA breaks via the microhomology-mediated
end joining (MMEJ) process. This causes apoptosis and inhibits proliferation in cancer
cells. GSK4524101may have a synergistic effect if administered in combination with
agents that cause DNA damage. Pol theta plays a key role in DNA synthesis and repair
that is highly expressed in cancer cells while nearly absent in most healthy tissues.
It plays a key role in cancer cell survival.;
Molecule name : GSK-4524101; GSK 4524101;
NCI Metathesaurus CUI : CL1921403;
Origin ID : C201946;
UMLS CUI : C5907939;
Semantic type(s)
- concept_is_in_subset
- has_target
