Inosine Triphosphate Pyrophosphatase

Preferred Label : Inosine Triphosphate Pyrophosphatase;

NCIt synonyms : ITPase; Non-Canonical Purine NTP Pyrophosphatase; Nucleoside-Triphosphate Pyrophosphatase; Nucleoside-Triphosphate Diphosphatase; ITPA; Non-Standard Purine NTP Pyrophosphatase; Inosine Triphosphate Pyrophosphohydrolase; Putative Oncogene Protein Hlc14-06-P; EC 3.6.1.9; NTPase; Inosine Triphosphatase;

NCIt definition : Inosine triphosphate pyrophosphatase (194 aa, 21 kDa) is encoded by the human ITPA gene. This protein plays a role in the removal of diphosphate from non-canonical purine nucleotide triphosphates.;

NCIt note : Substrates for inosine triphosphate pyrophosphatase include: inosine triphosphate (ITP), deoxyinosine triphosphate (dITP), 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP). (UniProt);

Details

Origin ID

C201843;

OMIM relation
- Inosine triphosphatase [OMIM gene]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- ITPA Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Nucleotide Biosynthesis Process [NCIt concept]

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