Preferred Label : Anti-claudin-1 Monoclonal Antibody ALE.C04;
NCIt synonyms : Anti-claudin 1 Monoclonal Antibody ALE.C04; Anti-CLDN1 Monoclonal Antibody ALE.C04;
NCIt definition : A humanized monoclonal antibody directed against the tumor-associated antigen (TAA)
claudin-1 (CLDN1; CLDN-1), with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CLDN1 monoclonal antibody ALE.C04 targets and binds to a
specific extracellular loop epitope that is exposed in non-junctional (NJ) CLDN1 expressed
on certain tumor cells. This prevents CLDN1-mediated signaling, which disrupts the
stiff extracellular matrix (ECM) in tumors and, by disturbing the physical barrier,
enhances the infiltration of immune cells, such as natural killer cells (NKs) and
T-cells. This abrogates immunosuppression in the tumor microenvironment (TME) and
leads to NK- and T-cell-mediated tumor cell killing. In addition, ALE.C04 can directly
kill CLDN1-expressing tumor cells via antibody-dependent cell mediated cytotoxicity
(ADCC). CLDN1, which is normally confined within the tight junctions in epithelial
tissues, is overexpressed on a variety of tumor cells in a non-junctional form. CLDN1
overexpression on tumor cells correlates with ECM remodeling and T-cell exclusion,
and is associated with reduced efficacy of checkpoint inhibitors (CPIs).;
Molecule name : ALE-C04; ALE.C04; ALE C04;
Origin ID : C201755;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
