Preferred Label : Anti-CD19/Anti-CD3/Anti-CD28 Trispecific Antibody CC312;
NCIt synonyms : Tri-specific T-cell Engager CC312; TriTE CC312; Anti-CD19/CD3/CD28 Trispecific Antibody CC312; CD19xCD3xCD28 Trispecific Antibody CC312;
NCIt definition : A trispecific T-cell engager and antibody targeting the tumor-associated antigen (TAA)
CD19, the T-cell surface antigen CD3, and the T-cell specific surface glycoprotein
and co-stimulatory molecule CD28, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CD19/anti-CD3/anti-CD28 trispecific antibody
CC312 targets and binds to CD3 and CD28 on T-cells and CD19 expressed on tumor cells.
The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response
against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface
antigen overexpressed in B-cell lineage malignancies.;
Molecule name : CC 312; CC-312;
Origin ID : C201656;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
