Preferred Label : 12-Lipoxygenase Inhibitor VLX-1005;
NCIt synonyms : N-2-benzothiazolyl-4-(((2-hydroxy-3-methoxyphenyl)methyl)amino)benzenesulfonamide; Benzenesulfonamide, N-2-benzothiazolyl-4-(((2-hydroxy-3-methyoxyphenyl)methyl)amino)-; 12-LOX Inhibitor VLX-1005;
NCIt related terms : VLX-1005;
NCIt definition : A selective small molecule inhibitor of 12-lipoxygenase (12-LOX), with potential anti-platelet
and anti-thrombotic activities. Upon intravenous administration, 12-LOX inhibitor
VLX-1005 inhibits platelet 12-LOX. This modulates Fc gamma receptor IIa (FcgRIIa;
CD32a) signaling, inhibits FcgRIIa-mediated platelet activation and aggregation, and
reduces thrombus formation. The activation of the FcgRIIa receptor plays an important
role in immune-mediated thrombosis, such as heparin-induced thrombocytopenia (HIT).
12-LOX, an enzyme expressed in platelets, regulates FcgRIIa activity in the platelet.;
UNII : JKU4XCC48Y;
CAS number : 1532593-30-8;
Molecule name : ML 355; VLX 1005; ML-355; VLX-1005;
NCI Metathesaurus CUI : CL1920783;
Origin ID : C201566;
UMLS CUI : C5853953;
Semantic type(s)
- concept_is_in_subset
- has_target
