Preferred Label : Beta-catenin Inhibitor FOG-001;
NCIt synonyms : Beta-catenin Antagonist FOG-001; TCF-blocking Beta-catenin Inhibitor FOG-001; Helicon FOG-001;
NCIt definition : A conformationally stabilized alpha-helical polypeptide and direct inhibitor of the
oncogenic driver beta-catenin, with potential immunomodulating and antineoplastic
activities. Upon administration, beta-catenin inhibitor FOG-001 penetrates into the
cell where it targets and binds to beta-catenin, thereby preventing the interaction
of beta-catenin with the transcriptional factor T-cell factor (TCF). This disrupts
beta-catenin-dependent oncogenic signaling and prevents the transcription of Wnt target
genes that regulate the proliferation, migration, invasion, and the metastatic potential
of tumor cells, as well as genes regulating the immunosuppression of the tumor microenvironment
(TME). Dysregulation of the Wnt/beta-catenin signaling pathway is found in a variety
of tumors and drives oncogenesis.;
Molecule name : FOG 001; FOG-001;
NCI Metathesaurus CUI : CL1920542;
Origin ID : C201235;
UMLS CUI : C5854643;
Semantic type(s)
- concept_is_in_subset
- has_target
