Preferred Label : Lead Pb 212 VMT-a-NET;
NCIt synonyms : [212Pb]VMT-a-NET; [212Pb] VMT-a-NET; Lead Pb 212 PSC-PEG2-TOC; Lead Pb 212 VMT-alpha-NET;
NCIt definition : A radioconjugate consisting of the human somatostatin receptor subtype 2 (SSTR2)-targeting
peptide and Tyr3-octreotide (TOC) analog, VMT-alpha-NET (VMT-a-NET), the N-terminus
of which is conjugated via a polyethylene glycol (PEG) linker, PEG2, to a lead (Pb)-specific
chelator (PSC) and bound to the alpha-emitting radioisotope lead Pb 212, with potential
antineoplastic activity. Upon administration of lead Pb 212 VMT-a-NET, the peptide
moiety specifically targets and binds to SSTR2, which is present on the cell membranes
of many types of neuroendocrine tumors (NETs). This allows for the specific delivery
of a cytotoxic dose of alpha radiation to SSTR2-positive cells. SSTR2 is overexpressed
on NETs and their metastases while most normal tissues express low levels of SSTR2.;
Origin ID : C201187;
concept_is_in_subset
- has_target
