NCIt synonyms : TCE Antibody ZG006; DLL3 x DLL3 x CD3 Trispecific Antibody ZG006; T-cell Engaging Antibody ZG006;
NCIt definition : A trispecific T-cell engaging (TCE) antibody directed against two different epitopes
of the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the T-cell surface
antigen CD3, with potential immunostimulating and antineoplastic activities. Upon
administration, anti-DLL3/DLL3/CD3 trispecific antibody ZG006 binds to both the CD3
antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing
tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which
results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch
pathway protein, is overexpressed on a variety of cancer cell types. It plays a key
role in embryonic development and in tumor initiation and proliferation.;
Semantic type(s)