Preferred Label : ERK1/2 Inhibitor D3S-002;
NCIt synonyms : ERK Inhibitor D3S-002;
NCIt definition : An orally bioavailable inhibitor of the extracellular signal-regulated kinases 1 (ERK1)
and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, ERK1/2
inhibitor D3S-002 specifically binds to and inhibits the serine/threonine-protein
kinase activities of both ERK1 and ERK2, thereby preventing the phosphorylation of
ERK1/2 substrates and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated
signal transduction pathways. This results in the inhibition of ERK-dependent proliferation
and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK
pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream
targets. It plays a key role in the proliferation, differentiation and survival of
tumor cells.;
Molecule name : D3S 002; D3S-002;
Origin ID : C200823;
concept_is_in_subset
- has_target
