Preferred Label : Diacylglycerol Kinase Zeta Inhibitor BGB-30813;
NCIt synonyms : DGK-zeta Inhibitor BGB-30813; DGKzeta Inhibitor BGB-30813;
NCIt definition : An orally bioavailable inhibitor of diacylglycerol kinase zeta (DGKzeta), with potential
antineoplastic activity. Upon oral administration, DGKzeta inhibitor BGB-30813 inhibits
the activity of DGKzeta. This prevents the phosphorylation of diacylglycerol (DAG)
to phosphatidic acid (PA), and modulates the DGKzeta-regulated cellular signaling
pathways. This may inhibit the proliferation of tumor cells in which DGKzeta is overactivated.
DGKzeta is overexpressed in certain cancer cells and plays an important role in tumor
cell survival. DGKzeta may also play a key role in tumor immunosuppression.;
Molecule name : BGB 30813; BGB-30813;
Origin ID : C200821;
concept_is_in_subset
- has_target
