Preferred Label : Anti-latent TGFb1 Monoclonal Antibody RO7496353;
NCIt synonyms : Anti-latent TGF-beta1 Monoclonal Antibody SOF10; Anti-latent TGF-beta1 Monoclonal Antibody RG6440; Anti-latent TGF-beta 1 Monoclonal Antibody RO7496353; Anti-latent TGF-beta1 Monoclonal Antibody RO7496353;
NCIt definition : A monoclonal antibody directed against latent human transforming growth factor (TGF)-beta
1 (TGFb1; TGF-b1), with potential antineoplastic activity. Upon administration, anti-latent
TGFb1 monoclonal antibody RO7496353 targets, binds to, and inhibits the activation
of latent TGFb1 complexes, thereby preventing TGFb1-mediated signaling. This abrogates
TGFb1-mediated immunosuppression, enhances anti-tumor immunity in the tumor microenvironment
(TME) and promotes a cytotoxic T-lymphocyte (CTL)-mediated immune response against
tumor cells leading to tumor cell death. This may lead to a reduction in TGFb1-dependent
proliferation of cancer cells. The TGF-beta signaling pathway is often deregulated
in tumors and plays a key role in the regulation of cell growth, differentiation,
apoptosis, motility, invasion, and angiogenesis. It plays a key role in immunosuppression
in the TME. TGFb1 is the predominant isoform in many tumors.;
Molecule name : SOF 10; RG 6440; RG-6440; RO 7496353; SOF-10; RO-7496353;
Origin ID : C200803;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
