Preferred Label : Allogeneic Anti-CD7 CAR-T Cells BEAM-201;
NCIt synonyms : Allogeneic Anti-CD7 CAR T Cells BEAM-201; Allogeneic Anti-CD7 CAR T-cells BEAM-201;
NCIt definition : A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that have been multiplex
base-edited and transduced with a lentiviral vector to express a chimeric antigen
receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential
immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD7
CAR-T cells BEAM-201 specifically target and kill CD7-expressing tumor cells. CD7
is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells
and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias
and lymphomas and in a subset of peripheral T-cell lymphomas.;
Molecule name : BEAM-201; BEAM 201;
NCI Metathesaurus CUI : CL1915071;
Origin ID : C200791;
UMLS CUI : C5854578;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
