7-Dehydrocholesterol Reductase

Preferred Label : 7-Dehydrocholesterol Reductase;

NCIt synonyms : EC 1.3.1.21; Delta7-Sterol Reductase; Sterol Reductase SR-2; Sterol Delta-7-Reductase; DHCR7; 7-DHC Reductase; Delta-7-Dehydrocholesterol Reductase; Sterol Delta(7)-Reductase;

NCIt definition : 7-dehydrocholesterol reductase (475 aa, 54 kDa) is encoded by the human DHCR7 gene. This protein is involved in reducing the C7-C8 double bonds in cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol during cholesterol biosynthesis.;

NCI Metathesaurus CUI : CL1915427;

Details

Origin ID

C200780;

UMLS CUI

C0049866;

OMIM relation
- 7-dehydrocholesterol reductase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 7-dehydrocholesterol reductase [MeSH Supplementary Concept]
- 7-dehydrocholesterol reductase [MeSH concept]
- 7-dehydrocholesterol reductase [SNOMED Notion]
gene_encodes_gene_product
- DHCR7 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Sterol Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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