Soluble Tyrosine-Protein Kinase Receptor UFO

Preferred Label : Soluble Tyrosine-Protein Kinase Receptor UFO;

NCIt synonyms : sAXL; Soluble AXL;

NCIt definition : Soluble tyrosine-protein kinase receptor UFO is encoded by the human AXL gene. The full-length tyrosine-protein kinase receptor UFO is a transmembrane protein and is subjected to ectodomain shedding via the activity of either disintegrin and metalloproteinase domain-containing protein 10 or 17, which yields a soluble form (sAXL). Although the function of this extracellular protein fragment is not well characterized, sAXL expression appears to correlate with the expression and activity of tyrosine-protein kinase receptor UFO. Additionally, serum levels of sAXL may be leveraged as a biomarker that aids in the detection of or prognosis for certain cancers.;

NCIt note : Soluble tyrosine-protein kinase receptor UFO maintains specificity for binding to growth arrest-specific protein 6 (GAS6).;

NCI Metathesaurus CUI : CL1915378;

Details

Origin ID

C200716;

UMLS CUI

C5848961;

OMIM relation
- Axl receptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AXL Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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