Microtubule-Associated Protein 1B

Preferred Label : Microtubule-Associated Protein 1B;

NCIt synonyms : Microtubule Associated Protein 1B; MAP-1B;

NCIt related terms : PURKINJE CELL CYTOPLASMIC TYPE 2 ANTIGEN; MAP5; MAP1B; PCA-2 Antigen;

NCIt definition : Microtubule-associated protein 1B (2468 aa, 271 kDa) is encoded by the human MAP1B gene. This protein plays a role in neurogenesis, tubulin binding and microtubule assembly.;

Alternative definition : CDISC: An antigen encoded by the MAP1B gene and is involved in microtubule assembly and neurogenesis. It can be considered as a neuronal autoantigen and is commonly associated with autoimmune neurodegenerative and paraneoplastic disorders related to cancer.;

NCIt note : Microtubule-associated protein 1B is proteolytically cleaved into two chains: MAP1B heavy chain and MAP1 light chain LC1. (UniProt); Microtubule-associated protein 1B has been identified as the autoantigen targeted by Purkinje cell cytoplasmic antibody type 2 (PCA-2), which is a marker for paraneoplastic neurologic syndrome. (Ann Neurol. 2017;81:266-277.);

PubMed : 28074593;

Details

Origin ID

C200654;

UMLS CUI

C1259521;

OMIM relation
- Microtubule-associated protein 1b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MAP1B protein, human [MeSH Supplementary Concept]
- MAP1B protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- MAP1B Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Microtubule [NCIt concept]
gene_product_is_element_in_pathway
- Lissencephaly-1 Gene in Neuronal Migration and Development [NCIt concept]
- Reelin Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Movement Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Microtubule Polymerization Process [NCIt concept]
- Microtubule Process [NCIt concept]
- Neural Development [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients