" /> Microtubule-Associated Protein 1B - CISMeF





Preferred Label : Microtubule-Associated Protein 1B;

NCIt synonyms : MAP1B; MAP-1B;

NCIt related terms : PURKINJE CELL CYTOPLASMIC TYPE 2 ANTIGEN; MAP5; Microtubule Associated Protein 1B; PCA-2 Antigen;

NCIt definition : Microtubule-associated protein 1B (2468 aa, 271 kDa) is encoded by the human MAP1B gene. This protein plays a role in neurogenesis, tubulin binding and microtubule assembly.;

Alternative definition : CDISC: An antigen encoded by the MAP1B gene and is involved in microtubule assembly and neurogenesis. It can be considered as a neuronal autoantigen and is commonly associated with autoimmune neurodegenerative and paraneoplastic disorders related to cancer.;

NCIt note : Microtubule-associated protein 1B is proteolytically cleaved into two chains: MAP1B heavy chain and MAP1 light chain LC1. (UniProt); Microtubule-associated protein 1B has been identified as the autoantigen targeted by Purkinje cell cytoplasmic antibody type 2 (PCA-2), which is a marker for paraneoplastic neurologic syndrome. (Ann Neurol. 2017;81:266-277.);

PubMed : 28074593;

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29/04/2024


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