" /> Formimidoyltransferase-Cyclodeaminase - CISMeF





Preferred Label : Formimidoyltransferase-Cyclodeaminase;

NCIt synonyms : FTCD; Formiminotransferase-Cyclodeaminase; Liver Cytosolic Antigen 1; EC 4.3.2.1; LCHC1; Formimidoyltransferase Cyclodeaminase; LC1 Antigen; Formiminotransferase Cyclodeaminase;

NCIt related terms : Liver Cytosol Type 1; LIVER CYTOSOLIC ANTIGEN TYPE 1; LC-1;

NCIt definition : Formimidoyltransferase-cyclodeaminase (541 aa, 59 kDa) is encoded by the human FTCD gene. This protein plays a role in both the conversion of tetrahydrofolate to 5-formimidoyltetrahydrofolate and the transfer of a formyl group from 5-formyltetrahydrofolate to L-glutamate.;

Alternative definition : CDISC: An antigen of the human liver 58 kDa cytosolic polypeptide encoded by the FTCD gene. It can be considered as an autoantigen and is commonly associated with type 2 autoimmune hepatitis.;

NCIt note : Autoantibodies against formimidoyltransferase-cyclodeaminase are associated with autoimmune hepatitis.; Formimidoyltransferase-cyclodeaminase has both glutamate formimidoyltransferase (EC 2.1.2.5) and formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activities.;

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28/04/2024


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