Paraneoplastic Antigen Ma2

Preferred Label : Paraneoplastic Antigen Ma2;

NCIt synonyms : Paraneoplastic Ma Antigen 2; Onconeuronal Antigen MA2; Paraneoplastic Neuronal Antigen MM2; PNMA Family Member 2; 40 kDa Neuronal Protein; PNMA2;

NCIt related terms : Ta Antigen; MA2 ANTIGEN;

NCIt definition : Paraneoplastic antigen Ma2 (364 aa, 42 kDa) is encoded by the human PNMA2 gene. This protein may be involved in the promotion of apoptosis in neurons.;

Alternative definition : CDISC: An antigen encoded by the PNMA2 gene and regulates apoptosis. It can be considered as a neuronal autoantigen and is commonly associated with autoimmune neurodegenerative disorders related to cancer, such as paraneoplastic neurologic syndrome.;

NCIt note : Autoantibodies against paraneoplastic antigen Ma2 are detectable in subjects suffering from testicular cancer and paraneoplastic limbic and/or brainstem encephalitis.;

Details

Origin ID

C200624;

OMIM relation
- Paraneoplastic ma antigen 2 [OMIM gene]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- PNMA2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
gene_product_has_associated_anatomy
- Nucleolus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]

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