Paraneoplastic Antigen Ma1

Preferred Label : Paraneoplastic Antigen Ma1;

NCIt synonyms : 37 kDa Neuronal Protein; PNMA Family Member 1; Paraneoplastic Neuronal Antigen MA1; Neuron- and Testis-Specific Protein 1; Paraneoplastic Ma Antigen 1;

NCIt related terms : MA1 ANTIGEN; PNMA1;

NCIt definition : Paraneoplastic antigen Ma1 (353 aa, 40 kDa) is encoded by the human PNMA1 gene. This protein may play a role in the regulation of apoptosis in neuronal and testicular cells.;

Alternative definition : CDISC: An antigen encoded by the PNMA1 gene that may promote apoptosis. It can be considered as a neuronal autoantigen and is commonly associated with autoimmune neurodegenerative disorders related to cancer, such as paraneoplastic neurologic syndrome.;

NCIt note : Autoantibodies against paraneoplastic antigen Ma1 are detectable in subjects suffering from paraneoplastic neurological disorders.;

NCI Metathesaurus CUI : CL1915311;

Details

Origin ID

C200621;

UMLS CUI

C5848971;

OMIM relation
- Paraneoplastic ma antigen 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- PNMA1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Testis [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleolus [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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