Preferred Label : Fluorine F 18-AIF-NOTA-pentixather;
NCIt synonyms : 18F-AlF-NOTA-pentixather; [18F]AlF-NOTA-pentixather;
NCIt definition : A radioconjugate composed of the pentapeptide pentixather, a chemokine receptor C-X-C
chemokine receptor type 4 (CXCR4)-targeting ligand, conjugated, via the macrocyclic
chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), to fluorine
F 18 radiolabeled aluminum fluoride ([18F]AIF), with potential diagnostic imaging
activity upon positron emission tomography (PET)/computed tomography (CT). Upon administration,
fluorine F 18-AIF-NOTA-pentixather targets and binds to CXCR4-expressing cells. This
allows for the visualization of CXCR4-expressing cells upon PET/CT. CXCR4, a G-protein-coupled
receptor and marker of poorly differentiated cells, is overexpressed on various cancer
cells and in aldosterone-producing tissues. It plays a key role in tumor growth, progression,
invasiveness and metastasis.;
NCI Metathesaurus CUI : CL1907549;
Origin ID : C200557;
concept_is_in_subset
- has_target
