Fluorine F 18-AIF-NOTA-pentixather

Preferred Label : Fluorine F 18-AIF-NOTA-pentixather;

NCIt synonyms : 18F-AlF-NOTA-pentixather; [18F]AlF-NOTA-pentixather;

NCIt definition : A radioconjugate composed of the pentapeptide pentixather, a chemokine receptor C-X-C chemokine receptor type 4 (CXCR4)-targeting ligand, conjugated, via the macrocyclic chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), to fluorine F 18 radiolabeled aluminum fluoride ([18F]AIF), with potential diagnostic imaging activity upon positron emission tomography (PET)/computed tomography (CT). Upon administration, fluorine F 18-AIF-NOTA-pentixather targets and binds to CXCR4-expressing cells. This allows for the visualization of CXCR4-expressing cells upon PET/CT. CXCR4, a G-protein-coupled receptor and marker of poorly differentiated cells, is overexpressed on various cancer cells and in aldosterone-producing tissues. It plays a key role in tumor growth, progression, invasiveness and metastasis.;

NCI Metathesaurus CUI : CL1907549;

Details

Origin ID

C200557;

UMLS CUI

C5856309;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- C-X-C Chemokine Receptor Type 4 [NCIt concept]

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