Preferred Label : Beta-catenin Antagonist ST316;
NCIt definition : A peptide antagonist of beta-catenin, with potential antineoplastic activity. Upon
administration, the beta-catenin antagonist ST316 targets and binds to beta-catenin,
thereby preventing the interaction between beta-catenin and its co-activator B-cell
CLL/lymphoma 9 protein (BCL9) and results in beta-catenin ubiquitin-mediated proteolysis.
This inhibits Wnt/beta-catenin oncogenic pathway signaling by preventing the translocation
of beta-catenin to the nucleus and preventing the transcription of Wnt target genes
that regulate the proliferation, migration, invasion, and the metastatic potential
of tumor cells, as well as genes regulating the immunosuppression of the tumor microenvironment
(TME). This results in tumor cell death and a pro-inflammatory TME. Constitutive activation
of the Wnt/beta-catenin signaling pathway plays a key role in promoting survival,
proliferation, and migration in various tumor cell types. BCL9, a co-activator of
beta-catenin's transcriptional activity, is overexpressed in many tumors and facilitates
beta-catenin's nuclear localization.;
Molecule name : ST-316; ST 316;
NCI Metathesaurus CUI : CL1907553;
Origin ID : C200553;
UMLS CUI : C5854561;
Semantic type(s)
- concept_is_in_subset
- has_target
