Preferred Label : Anti-CD137 Monoclonal Antibody PE0116;
NCIt synonyms : Anti-4-1BB Monoclonal Antibody PE0116;
NCIt definition : A human immunoglobulin G4 (IgG4) agonistic monoclonal antibody directed against the
inducible T-cell costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor
superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CD137 monoclonal antibody PE0116 is selectively
activated in the tumor microenvironment (TME), and targets, binds to, crosslinks and
activates CD137 expressed on a variety of leukocyte subsets including activated T-lymphocytes
and natural killer (NK) cells. This enhances CD137-mediated signaling, induces T-cell
proliferation, cytokine production and promotes T-cell mediated anti-tumor immune
responses. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily,
is an inducible costimulatory receptor that plays a key role in T-cell proliferation,
survival and cytolytic activity to promote anti-tumor immunity.;
Molecule name : PE 0116; PE-0116;
NCI Metathesaurus CUI : CL1907545;
Origin ID : C200545;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
