Anti-CD137 Monoclonal Antibody PE0116

Preferred Label : Anti-CD137 Monoclonal Antibody PE0116;

NCIt synonyms : Anti-4-1BB Monoclonal Antibody PE0116;

NCIt definition : A human immunoglobulin G4 (IgG4) agonistic monoclonal antibody directed against the inducible T-cell costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD137 monoclonal antibody PE0116 is selectively activated in the tumor microenvironment (TME), and targets, binds to, crosslinks and activates CD137 expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces T-cell proliferation, cytokine production and promotes T-cell mediated anti-tumor immune responses. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity to promote anti-tumor immunity.;

Molecule name : PE 0116; PE-0116;

NCI Metathesaurus CUI : CL1907545;

Details

Origin ID

C200545;

UMLS CUI

C5854554;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 9 [NCIt concept]

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