Preferred Label : RIP1 Inhibitor GDC-8264;
NCIt synonyms : RIPK1 Inhibitor GDC-8264; RIP1 Kinase Inhibitor GDC-8264;
NCIt definition : An orally available inhibitor of receptor-interacting serine/threonine-protein kinase
1 (RIPK1; receptor-interacting protein 1; RIP1) with potential immunomodulatory and
anti-inflammatory activities. Upon oral administration, RIP1 inhibitor GDC-8264 inhibits
RIP1-mediated signaling, which may preserve intestinal stem cells (ISCs) and prevent
RIP1-mediated gastrointestinal (GI) damage in acute graft-versus-host disease (GvHD).
RIP1 plays a key role in inflammation and cell death in response to tissue damage
and pathogen recognition.;
Molecule name : RG-6287; GDC 8264; GDC-8264; RG 6287;
NCI Metathesaurus CUI : CL1907518;
Origin ID : C200516;
concept_is_in_subset
- has_target
