Preferred Label : RAS Peptide Cancer Vaccine TG01;
NCIt synonyms : Ras Vaccine TG01; Mutant RAS Cancer Vaccine TG01; Cancer Vaccine TG01; KRAS Peptide Cancer Vaccine TG01;
NCIt definition : A therapeutic cancer vaccine containing seven 17 amino acids long synthetic RAS oncogene-encoded
peptides representing the most common codon 12 and 13 oncogenic mutations in Kirsten
rat sarcoma viral oncogene homolog (KRAS), with potential immunomodulating and antineoplastic
activities. Upon administration, RAS peptide cancer vaccine TG01 may stimulate a specific
CD4-positive helper T-lymphocyte- and cytotoxic T-lymphocyte (CTL)-mediated immune
response against RAS mutant-specific-expressing cancer cells, resulting in an inhibition
of tumor cell proliferation and tumor cell death. Mutations in RAS genes are found
in the majority of pancreatic cancers.;
Molecule name : TG-01; TG 01;
NCI Metathesaurus CUI : CL1907472;
Origin ID : C200465;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
