Preferred Label : RAS Peptide Cancer Vaccine TG01;
NCIt synonyms : Ras Vaccine TG01; Mutant RAS Cancer Vaccine TG01; Cancer Vaccine TG01; KRAS Peptide Cancer Vaccine TG01; TG01 Reconstituted with QS-21;
NCIt definition : A therapeutic cancer vaccine composed of a lyophilizate containing seven 17 amino
acids long synthetic RAS oncogene-encoded peptides representing the most common codon
12 and 13 oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS),
with potential immunomodulating and antineoplastic activities. The lyophilizate is
reconstituted with the natural saponin and immunoadjuvant QS-21 before administration.
Upon administration, RAS peptide cancer vaccine TG01 may stimulate a specific CD4-positive helper
T-lymphocyte- and cytotoxic T-lymphocyte (CTL)-mediated immune response against RAS
mutant-specific-expressing cancer cells, resulting in an inhibition of tumor cell
proliferation and tumor cell death. Mutations in RAS genes are found in various cancers.;
Semantic type(s)