Preferred Label : Gallium Ga 68-labeled alphaVbeta6 Binding Peptide RAD 301;
NCIt synonyms : Radiotracer RAD 301; 68Ga-Trivehexin; Gallium Ga 68 Trivehexin;
NCIt definition : A radiotracer composed of RAD301, which comprises an integrin alphaVbeta6 (aVb6) binding
peptide (BP) and is radiolabeled with the radionuclide gallium Ga 68, with potential
integrin aVb6 imaging activity using positron emission tomography (PET). Upon administration
of gallium Ga 68-labeled alphaVbeta6 binding peptide RAD301, the aVb6-binding peptide
moiety selectively targets and binds to integrin aVb6-positive cancer cells. During
PET, aVb6-expressing tumor cells can be visualized and the degree of tumor growth
can be determined. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated
in certain cancer cell types and has been associated with increased proliferation,
migration and invasion of tumor cells.;
Molecule name : RAD 301; RAD-301;
NCI Metathesaurus CUI : CL1907473;
Origin ID : C200464;
concept_is_in_subset
- has_target
