Preferred Label : Anti-MUC16/Anti-CD3 Bispecific Antibody LBL-033;
NCIt synonyms : Anti-MUC16/CD3 Bispecific Antibody LBL-033; T-cell Engager LBL-033;
NCIt definition : A bispecific monoclonal antibody containing one arm targeting human CD3, a T-cell
surface antigen that is part of the T-cell receptor (TCR) complex, and two arms targeting
the membrane-proximal domain of the tumor-associated antigen (TAA) human mucin 16
(MUC16, cancer antigen 125; CA125; FLJ14303), with potential antineoplastic activity.
Upon administration, anti-MUC16/anti-CD3 bispecific antibody LBL-033 binds to both
T-cells and MUC16-expressing tumor cells, which cross-links the T-cells to the tumor
cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against the
MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins,
is overexpressed on a variety of cancer cell types. BY binding in a 2:1 ratio to MUC16
and CD3, LBL-033 improves aggregation in MUC16-overexpressing tumor cells while reducing
the non-specific activation of CD3. This may improve efficacy and minimize potential
systemic toxicity, such as cytokine release syndrome (CRS).;
Molecule name : LBL-033; LBL 033;
NCI Metathesaurus CUI : CL1907468;
Origin ID : C200458;
UMLS CUI : C5854538;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
