Preferred Label : Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells;
NCIt synonyms : TROP2-CAR-engineered IL15-transduced Cord Blood-derived NKs; TROP2-CAR-IL-15 CBNKs; TROP2-CAR/IL15-transduced CBNK Cells; Anti-TROP2-CAR-IL-15-transduced CB-derived NK Cells; Anti-TROP2CAR/IL15-transduced CB-NK Cells; Anti-TROP2-CAR-IL-15-expressing CB-NK Cells;
NCIt definition : A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) that
have been engineered to express a chimeric antigen receptor (CAR) specific for the
tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen
2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1;
M1S1) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-TROP2-CAR-IL-15-transduced CB-derived NK cells
target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells.
IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte
lineages and potentiates the immune response against tumor cells. TROP2 is a transmembrane
protein overexpressed in various tumors. Its expression is associated with enhanced
tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.;
NCI Metathesaurus CUI : CL1907144;
Origin ID : C200344;
UMLS CUI : C5856200;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
