NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against discoid
domain receptor type 1 (DDR1), with potential immunomodulating and antineoplastic
activities. Upon administration, anti-DDR1 monoclonal antibody PRTH-101 specifically
targets, binds to and blocks DDR1, a protein expressed on tumor cells that binds collagen
to make a minimally permeable physical barrier that blocks immune cells in the tumor
microenvironment (TME) from interacting with and attacking the tumor. By blocking
DDR1, PRTH-101 causes the collagen fibers to lose alignment and loosen. This creates
gaps in the tumor barrier, thereby allowing cytotoxic T-cells to enter and attack
the tumor.;
Semantic type(s)