Preferred Label : Allogeneic Anti-interleukin-13 Receptor Alpha 2 Universal CAR-T Cells;
NCIt synonyms : Allogeneic Anti-IL13Ra2 Universal CAR T-cells; Allogeneic Anti-IL-13 Ra2 UCAR-T Cells; Allogeneic Anti-IL13Ra2 Universal CAR T Cells; Allogeneic Anti-IL13Ra2 UCAR-T Cells; Allogeneic IL-13 Ra2 UCAR-T Cells;
NCIt definition : A preparation of allogeneic, off-the-shelf (OTS), universal, gene-edited T-lymphocytes
expressing a chimeric antigen receptor (CAR) specific for interleukin-13 receptor
alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities.
Upon administration, allogeneic anti-IL13Ra2 UCAR-T cells target and bind to IL13Ra2
expressed on the surface of tumor cells. This induces selective toxicity in tumor
cells expressing IL13Ra2. IL13Ra2, a cancer-associated receptor, is overexpressed
by a variety of tumor cell types including glioblastoma multiforme (GBM); it is associated
with increased invasiveness of tumor cells.;
NCI Metathesaurus CUI : CL1907104;
Origin ID : C200279;
concept_is_in_subset
- has_target
