NCIt definition : A humanized monoclonal antibody directed against Dickkopf-related protein 1 (Dickkopf-1;
DKK1), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-DKK1 monoclonal antibody JS015 binds to DKK1 and blocks the interaction between
DKK1 and its ligands low-density lipoprotein receptor-related proteins (LRP) 5 and
6. This restores signaling through the Wnt/beta-catenin-dependent (canonical) pathway,
and may decrease DKK1-mediated immunosuppressive effects in the tumor microenvironment
(TME) and enhance anti-tumor immune responses. DKK1, an inhibitor of the Wnt/beta-catenin-dependent
(canonical) signaling pathway, is overexpressed by and dysregulated in some cancers,
as well as other diseases including osteoporosis, Alzheimer's disease and diabetes.;
Semantic type(s)